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The mechanisms driving central sensitization include elevated substance P, reduced descending pain inhibition, altered glutamate signaling, and microglial activation in the central nervous system

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NA-AION, recognized as the most common form of ischemic optic neuropathy and the second most frequent optic neuropathy after glaucoma, carries an estimated annual incidence of 10.3 per 100,000, typically affecting individuals around the age of 72 [522,523]

Mice were then treated intraperitoneally with erastin or ferrostatin-1 (20 mg/kg